Description

n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide is a specialized organosilicon reagent primarily used as a powerful derivatization agent in analytical chemistry. Its core value lies in its ability to effectively silylate a wide range of polar functional groups, enhancing the volatility and thermal stability of analytes for gas chromatographic analysis. This compound is essential for analytical scientists and quality control professionals in the pharmaceutical, environmental, and forensic sectors who require precise and reliable sample preparation for GC and GC-MS applications.

Application

• GC and GC-MS Derivatization: A key reagent for silylating alcohols, phenols, carboxylic acids, and amines to improve their chromatographic performance.
• Pharmaceutical Analysis: Used in the quantification of drug metabolites, impurities, and active pharmaceutical ingredients (APIs) with polar groups.
• Metabolomics and Biomarker Discovery: Facilitates the analysis of complex biological samples by derivatizing metabolites for profiling studies.
• Environmental Testing: Employed in the detection and analysis of pesticides, herbicides, and other environmental contaminants.
• Forensic Toxicology: Supports the identification and quantification of drugs of abuse and poisons in biological specimens.
• Polymer and Material Science: Acts as a silylating agent for surface modification and analysis of polymeric materials.

Basic Information

Product Name	n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide
CAS No.	945623-67-6
Molecular Formula	C7H14F3NOSi
Molecular Weight	201.28 g/mol
Synonyms	MSTFA; N-Methyl-N-(trimethylsilyl)trifluoroacetamide; N-Methyl-N-trimethylsilyltrifluoroacetamide; Trimethylsilylating Reagent MSTFA; N-Methyl-N-(trimethylsilyl)-2,2,2-trifluoroacetamide; Derivatization Reagent MSTFA; Silylation Agent MSTFA; TMS Derivative Reagent
EINECS	Contact for details

Quality Control

Our n-Methyl-n-(Trimethylsilyl)Trifluoroacetamide is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific customer requirements for research or regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.