Description

4-Isothiocyanatobenzenesulfonic Acid, Sodium Salt Monohydrate is a versatile, water-soluble chemical intermediate featuring both a reactive isothiocyanate group and a sulfonate moiety. This bifunctional nature makes it a valuable building block for the synthesis of sulfonated dyes, fluorescent labeling reagents, and specialized polymers. It is primarily sought after by research institutions and industrial manufacturers in the life sciences, analytical chemistry, and specialty chemical sectors for creating conjugates and functional materials.

Application

• Fluorescent Labeling & Bioconjugation: Acts as a key reagent for labeling proteins, antibodies, and other biomolecules with fluorescent probes due to its reactive isothiocyanate group, which readily forms stable thiourea bonds with primary amines.
• Sulfonated Dye Synthesis: Serves as a critical intermediate in the production of water-soluble, anionic dyes and pigments for textiles, inks, and biological staining applications.
• Polymer Modification: Used to introduce hydrophilic sulfonate groups and reactive sites into polymer backbones, enhancing solubility and enabling further functionalization for advanced material science.
• Analytical Reagent: Employed in the development of chromatographic derivatization agents and other analytical tools for detecting amines and other nucleophiles.
• Pharmaceutical Intermediate: Utilized in research-scale synthesis of drug candidates and diagnostic agents that require sulfonate functionality for improved solubility or targeting.
• Cross-linking Agent: Functions as a homobifunctional cross-linker in material science and biochemistry to create networks or conjugate molecules.

Basic Information

Product Name	4-Isothiocyanatobenzenesulfonic Acid, Sodium Salt Monohydrate
CAS No.	17614-69-6
Molecular Formula	C7H4NNaO4S2 • H2O
Molecular Weight	279.23 g/mol (Monohydrate)
Synonyms	Benzenesulfonic acid, 4-isothiocyanato-, sodium salt, monohydrate; Sodium 4-isothiocyanatobenzenesulfonate monohydrate; p-Isothiocyanatobenzenesulfonic acid sodium salt monohydrate; 4-Isothiocyanatobenzene-1-sulfonic acid sodium salt hydrate; FITC-BSA sulfonate precursor; Reactive sulfonate dye intermediate; Sodium p-isothiocyanatobenzenesulfonate
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanatobenzenesulfonic Acid, Sodium Salt Monohydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, FT-IR for identification, and Karl Fischer titration for water content, to ensure it meets precise specifications for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture, which may affect performance and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	5.0 - 8.0% (Theoretical for monohydrate: ~6.45%)
Heavy Metals (as Pb)	≤ 20 ppm
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.