Description

Methyl Isobutyl Ketone-Dnph is a high-purity derivative of methyl isobutyl ketone (MIBK), specifically the 2,4-dinitrophenylhydrazone (DNPH) adduct, used as a critical analytical standard and reagent. This compound is essential for the accurate quantification and identification of carbonyl compounds, particularly ketones and aldehydes, in complex matrices. It is primarily required by analytical laboratories, environmental testing facilities, and quality control departments in the chemical and pharmaceutical industries for precise chromatographic analysis and method validation.

Application

• Analytical Reference Standard: Serves as a primary standard for the calibration of HPLC, GC, and LC-MS systems in carbonyl compound analysis.
• Environmental Monitoring: Used in the derivatization and subsequent detection of airborne carbonyl pollutants (e.g., formaldehyde, acetaldehyde) following EPA and ISO methods.
• Pharmaceutical QC: Employed in impurity profiling and residual solvent analysis to ensure drug substance and product purity.
• Food and Flavor Analysis: Applied in the determination of carbonyl compounds that are key flavor constituents or potential contaminants.
• Material Testing: Used in the analysis of volatile organic compounds (VOCs) emitted from polymers, coatings, and consumer products.
• Research and Development: A vital reagent in synthetic chemistry and metabolic studies for trapping and characterizing reactive carbonyl intermediates.

Basic Information

Product Name	Methyl Isobutyl Ketone-Dnph
CAS No.	1655-42-1
Molecular Formula	C13H18N4O4
Molecular Weight	294.31 g/mol
Synonyms	MIBK-DNPH; 4-Methyl-2-pentanone 2,4-dinitrophenylhydrazone; Methyl Isobutyl Ketone 2,4-Dinitrophenylhydrazone; MIBK derivative with DNPH; 2,4-Dinitrophenylhydrazone of 4-Methylpentan-2-one; Isopropylacetone DNPH derivative; Hexone DNPH; (E)-1-(2,4-Dinitrophenyl)-2-(4-methylpentan-2-ylidene)hydrazine
EINECS	Contact for details

Quality Control

Our Methyl Isobutyl Ketone-Dnph is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by FT-IR and melting point, to ensure it meets the stringent requirements for use as an analytical standard. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Melting Point	Specified range
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, chloroform; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.