Description

4-Nitrobenzofurazan is a specialized heterocyclic organic compound, recognized for its role as a versatile derivatization reagent and analytical probe. Its primary commercial value lies in its strong electrophilic character and ability to form stable, highly fluorescent or colored adducts with nucleophiles, making it an essential tool for detection and quantification. This product is critical for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors who require sensitive and selective methods for analyzing amines, thiols, and other nucleophilic compounds.

Application

• Derivatization agent in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) for the sensitive detection of aliphatic amines and amino acids.
• Fluorescent labeling reagent for biomolecules, including proteins and peptides, in biochemical research and assay development.
• Chromogenic probe for the qualitative and quantitative analysis of sulfhydryl groups (thiols) in various chemical and biological samples.
• Intermediate in the synthesis of more complex furazan-based heterocycles for material science and pharmaceutical research.
• Reagent for the spectrophotometric determination of trace metals and anions that form complexes with the nitrobenzofurazan moiety.
• Chemical sensor component in the development of detection kits for environmental monitoring and diagnostic applications.

Basic Information

Product Name	4-Nitrobenzofurazan
CAS No.	16322-19-3
Molecular Formula	C6H3N3O3
Molecular Weight	165.11 g/mol
Synonyms	4-Nitro-2,1,3-benzoxadiazole; NBD-Cl; 4-Nitrobenzo-2-oxa-1,3-diazole; 7-Nitro-2,1,3-benzoxadiazole; 4-Nitrobenzofuroxan; 4-Nitro-2,1,3-benzoxadiazole; NBD; 4-Nitrobenzo[c][1,2,5]oxadiazole
EINECS	Contact for details

Quality Control

Our 4-Nitrobenzofurazan is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification (IR), purity assay (HPLC), and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, minimize exposure to light during handling and storage.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	97 - 102 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.