Description

Pyridine, 2-Methyl-3-[(2S)-2-Pyrrolidinylmethoxy]-, (2R,3R)-2,3-Dihydroxybutanedioate (1:1) is a high-purity, complex organic salt with a defined stereochemistry, making it a critical intermediate for advanced pharmaceutical synthesis. This compound matters because its precise chiral structure is essential for developing active pharmaceutical ingredients (APIs) with high enantiomeric purity and targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of neurology and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral drug candidates and active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the development of compounds targeting nicotinic acetylcholine receptors for potential cognitive and neurological therapies.
• Chemical Biology Probe: Serves as a precise tool for studying enzyme-substrate interactions and signal transduction pathways due to its defined stereochemistry.
• Asymmetric Synthesis Catalyst: Potential use as a ligand or precursor in catalysts for enantioselective chemical transformations.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex molecules under Good Manufacturing Practice (GMP) conditions.

Basic Information

Item	Detail
Product Name	Pyridine, 2-Methyl-3-[(2S)-2-Pyrrolidinylmethoxy]-, (2R,3R)-2,3-Dihydroxybutanedioate (1:1)
CAS No.	945405-37-8
Molecular Formula	C15H24N2O7
Molecular Weight	344.36 g/mol
Synonyms	(2R,3R)-2,3-Dihydroxybutanedioic acid compound with 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine (1:1); 2-Methyl-3-((S)-2-pyrrolidinylmethoxy)pyridine (R,R)-tartrate; (R,R)-Tartaric acid salt of 2-methyl-3-((S)-2-pyrrolidinylmethoxy)pyridine; ABT-089 precursor salt; GTS-21 related intermediate; DMXB-A tartrate; Cholinergic nicotinic receptor ligand intermediate
EINECS	Contact for details

Quality Control

Our Pyridine, 2-Methyl-3-[(2S)-2-Pyrrolidinylmethoxy]-, (2R,3R)-2,3-Dihydroxybutanedioate (1:1) is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure consistent stereochemical integrity and chemical purity. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.