Description

6-Fluorochroman-3-Carboxylic Acid is a high-purity fluorinated chroman derivative, a crucial chiral building block in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which combines a fluorinated aromatic system with a carboxylic acid functional group, enabling precise structural modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorophore-tagged molecules and activity-based probes in biochemical research.

Basic Information

Product Name	6-Fluorochroman-3-Carboxylic Acid
CAS No.	944899-27-8
Molecular Formula	C10H9FO3
Molecular Weight	196.18 g/mol
Synonyms	3-Chromancarboxylic acid, 6-fluoro-; 6-Fluoro-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid; 6-Fluoro-3-chromancarboxylic acid; 6-Fluorochroman-3-carboxylic acid; (3R)-6-Fluorochroman-3-carboxylic acid (enantiomer); (3S)-6-Fluorochroman-3-carboxylic acid (enantiomer); 6-Fluoro-2,3-dihydro-4H-chromene-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Fluorochroman-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.