Description

1-Aminoindan Sulfate (Rasagiline) is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its core value lies in its critical role as the sulfate salt of Rasagiline, a potent and selective monoamine oxidase-B (MAO-B) inhibitor used in the treatment of Parkinson's disease. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring a reliable, high-quality building block for neurological therapeutics. Global demand is driven by the need for consistent, scalable synthesis of this key therapeutic agent.

Application

• Primary Pharmaceutical Ingredient: Direct synthesis of Rasagiline mesylate, the active drug substance in medications for Parkinson's disease.
• API Intermediate: Serves as a crucial chemical precursor in the multi-step synthesis of final Rasagiline drug products.
• Neurological Research: Used as a reference standard and active compound in preclinical and clinical research focused on MAO-B inhibition and neurodegenerative disorders.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing novel analogs and derivatives for pharmacological screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of generic and branded neurological pharmaceuticals.
• Regulatory Submissions: Sourced for the preparation of Drug Master Files (DMFs) and regulatory documentation for health authorities worldwide.

Basic Information

Product Name	1-Aminoindan Sulfate (Rasagiline)
CAS No.	936474-09-8
Molecular Formula	C9H11N • H2SO4
Molecular Weight	229.26 g/mol
Synonyms	Rasagiline Sulfate; (1R)-1-Aminoindan Sulfate; (R)-1-Aminoindan Sulfate; (R)-(-)-1-Aminoindan Sulfate; AGN-1135 Sulfate; TVP-1012 Sulfate; N-Propargyl-1(R)-aminoindan Sulfate; 1H-Inden-1-amine, 2,3-dihydro-, (1R)-, sulfate (1:1)
EINECS	Contact for details

Quality Control

Our 1-Aminoindan Sulfate (Rasagiline) is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Quality is assured through comprehensive analytical testing including HPLC for assay and purity, chiral purity determination, and control of residual solvents and impurities. A Certificate of Analysis (COA) is provided with each batch, documenting compliance with agreed specifications. We support customer audits and regulatory filings, with production potentially aligned to GMP (Good Manufacturing Practice) standards for API intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.