Description

Nitecapone CAS NO 116313-94-1 is a potent and selective catechol-O-methyltransferase (COMT) inhibitor. This compound is of significant interest in pharmaceutical research and development, particularly for its potential to enhance the efficacy of levodopa-based therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for neurological disorders such as Parkinson's disease.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced COMT inhibitor drug candidates.
• Neurological Research: Used as a reference standard and active compound in preclinical studies targeting Parkinson's disease.
• Biochemical Assay Development: Employed as a tool compound to study COMT enzyme kinetics and inhibition mechanisms.
• Metabolite Synthesis: Utilized in the preparation of metabolites for pharmacokinetic and pharmacodynamic studies.
• Academic Research: Serves as a critical reagent in university and institutional labs focusing on neuropharmacology.

Basic Information

Product Name	Nitecapone
CAS No.	116313-94-1
Molecular Formula	C14H11NO4
Molecular Weight	257.24 g/mol
Synonyms	3-(3,4-Dihydroxy-5-nitrophenyl)propenamide; OR-462; (E)-3-(3,4-Dihydroxy-5-nitrophenyl)acrylamide; 3-(3,4-Dihydroxy-5-nitrophenyl)acrylamide; Nitecapone (INN); (E)-Nitecapone
EINECS	Contact for details

Quality Control

Our Nitecapone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.