Description

Rivanicline CAS NO 15585-43-0 is a high-purity pharmaceutical intermediate and research chemical of significant interest in medicinal chemistry. Its primary value lies in its role as a key building block for the synthesis of novel nicotinic acetylcholine receptor (nAChR) ligands and other bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery, process development, and the production of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted nAChR modulators and other central nervous system (CNS) active compounds.
• Drug Discovery & Research: Serves as a versatile scaffold in medicinal chemistry for designing and optimizing new chemical entities with potential therapeutic applications.
• Process Chemistry & Scale-up: Used in the development and optimization of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of nicotinic receptor ligands.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Rivanicline
CAS No.	15585-43-0
Molecular Formula	C11H14N2O2
Molecular Weight	206.24 g/mol
Synonyms	Rivanicline; 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octan-3-one; 3-Pyridinylquinuclidin-2-one; TC-2403; SSR-591813; (R)-2-(3-Pyridyl)-1-azabicyclo[2.2.2]octan-3-one; (R)-Rivanicline; (S)-Rivanicline (enantiomer)
EINECS	Contact for details

Quality Control

Our Rivanicline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) documenting full specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiomer-specific grade)
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.