Description

Benserazide Hydrochloride is a potent peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor, primarily used in combination with levodopa for the treatment of Parkinson's disease. This combination therapy enhances the bioavailability of levodopa in the central nervous system, improving motor control and reducing peripheral side effects. It is a critical active pharmaceutical ingredient (API) for pharmaceutical manufacturers developing and producing anti-Parkinsonian medications.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of combination drugs for Parkinson's disease therapy.
• Key component in the production of Levodopa/Benserazide combination tablets (e.g., Madopar, Prolopa).
• Used in pharmaceutical research and development for studying dopaminergic pathways and neurodegenerative disorders.
• Essential raw material for generic drug manufacturers producing anti-Parkinsonian medications.
• Potential applications in veterinary medicine for similar neurological conditions in animals.
• Reference standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Benserazide Hydrochloride
CAS No.	14919-77-8
Molecular Formula	C10H15N3O5 • HCl
Molecular Weight	293.71 g/mol
Synonyms	Benserazide HCl; DL-Seryl-2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride; Ro 4-4602; Serazide Hydrochloride; (RS)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride; L-Seryl-trihydroxybenzylhydrazine hydrochloride; Trihydroxybenzylhydrazine serine hydrochloride
EINECS	238-984-8

Quality Control

Our Benserazide Hydrochloride is manufactured under strict quality systems suitable for pharmaceutical applications. It is produced and tested to meet in-house specifications aligned with major pharmacopoeial standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.