Description

(Alphas)-n-[(1S)-2-[[(5S)-4,5-Dihydro-3-Methyl-4-Oxo-3H-2,3-Benzodiazepin-5-Yl]Amino]-1-Methyl-2-Oxoethyl]-3,5-Difluoro-α-Hydroxybenzeneacetamide is a high-purity, non-racemic chiral compound designed for advanced research and development. This molecule serves as a critical pharmaceutical intermediate or reference standard in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in neurological and psychiatric domains.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Research & Development: Used as a reference standard or starting material in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target drug molecules.
• Analytical Standard: Serves as a high-purity calibrant for method development and validation in quality control (QC) laboratories.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological screening and toxicological evaluation.

Basic Information

Product Name	(Alphas)-n-[(1S)-2-[[(5S)-4,5-Dihydro-3-Methyl-4-Oxo-3H-2,3-Benzodiazepin-5-Yl]Amino]-1-Methyl-2-Oxoethyl]-3,5-Difluoro-α-Hydroxybenzeneacetamide
CAS No.	935525-13-6
Molecular Formula	C21H21F2N3O5
Molecular Weight	433.41 g/mol
Synonyms	3,5-Difluoro-α-hydroxy-N-[(1S)-2-[[(5S)-3-methyl-4-oxo-4,5-dihydro-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]benzeneacetamide; (αS)-3,5-Difluoro-α-hydroxy-N-[(1S)-1-methyl-2-oxo-2-[[(5S)-3-methyl-4-oxo-4,5-dihydro-3H-2,3-benzodiazepin-5-yl]amino]ethyl]benzeneacetamide; UNII-2X3R6X8P4F; Benzeneacetamide, 3,5-difluoro-α-hydroxy-N-[(1S)-2-[[(5S)-3-methyl-4-oxo-4,5-dihydro-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-, (αS)-; A potential intermediate for GSK-3 inhibitors.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.