Description

Pimavanserin is a highly selective serotonin inverse agonist and antagonist, specifically targeting the 5-HT2A receptor. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of novel neurological therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in advanced central nervous system (CNS) drug development and production.

Application

• Primary Pharmaceutical Ingredient: Serves as the key active component in the formulation of antipsychotic medications for Parkinson's disease psychosis.
• Neurological Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting serotonin receptors.
• Drug Development: Essential for R&D teams developing new treatments for schizophrenia, Alzheimer's disease-related psychosis, and other CNS disorders.
• Generic API Manufacturing: Sourced by manufacturers producing generic versions of approved pimavanserin-based drugs.
• Analytical Standard: Employed in quality control laboratories for HPLC, LC-MS, and spectroscopic method development and validation.
• Clinical Trial Material (CTM): Supplied as a GMP-grade intermediate for the synthesis of drug products used in clinical trials.

Basic Information

Product Name	Pimavanserin
CAS No.	932724-63-5
Molecular Formula	C25H34FN3O2
Molecular Weight	427.56 g/mol
Synonyms	ACP-103; 1-(4-Fluorobenzyl)-3-(4-(2-methylpropoxy)benzyl)urea; N-(4-Fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropoxy)phenyl)methylurea; Pimavanserin Tartrate (salt form precursor); NUPLAZID (brand name API)
EINECS	Contact for details

Quality Control

Our Pimavanserin is manufactured under strict quality management systems. We offer material suitable for research and GMP-grade applications, with comprehensive testing to ensure identity, purity, and consistency. All batches are supported by a detailed Certificate of Analysis (COA) that includes results from HPLC for assay and impurity profiling, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals. Specifications are designed to meet or exceed relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.