Description

Serlopitant is a potent and selective small-molecule antagonist of the neurokinin-1 (NK1) receptor. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for conditions mediated by substance P, such as chronic pruritus, depression, and anxiety disorders. Serlopitant CAS NO 931395-42-5 represents a key intermediate or active pharmaceutical ingredient (API) for advanced clinical and preclinical studies.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and building block in the discovery and development of new neurokinin-1 receptor antagonist drugs.
• Clinical Research: Used as an active pharmaceutical ingredient (API) in formulations for clinical trials targeting chronic pruritus (itch) associated with conditions like atopic dermatitis and psoriasis.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate the pharmacological profile and efficacy of NK1 receptor blockade.
• Neurological & Psychiatric Research: A tool compound for studying the role of substance P and the NK1 receptor in depression, anxiety, and emesis (vomiting).
• Chemical Synthesis: Acts as a high-purity intermediate for the synthesis of more complex molecules or derivative compounds in medicinal chemistry.
• Analytical Testing: Used as a certified reference material (CRM) in HPLC, LC-MS, and NMR for method development, validation, and quality control.

Basic Information

Product Name	Serlopitant
CAS No.	931395-42-5
Molecular Formula	C₂₄H₂₈N₄O₂
Molecular Weight	404.51 g/mol
Synonyms	VPD-737; (R)-N-((S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl)-6-(4-fluoro-2-methylphenyl)-2-(methyl(2-(methylamino)pyrimidin-5-yl)amino)nicotinamide; Serlopitant Maleate (salt form precursor); NK1 Receptor Antagonist VPD-737; UNII-9V6R9L6Q5P; 5-Pyrimidinamine, N-methyl-2-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]amino]-N-[5-(4-fluoro-2-methylphenyl)-3-pyridinyl]methyl]-
EINECS	Contact for details

Quality Control

Our Serlopitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) that detail specifications including assay, related substances, residual solvents, and heavy metals, compliant with ICH guidelines. Our quality commitment supports its use in GMP-grade pharmaceutical applications and rigorous research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.