Description

Pentafluorophenyl 4-(Tetrahydropyran-4-Yloxy)Benzoate is a specialized fluorinated aromatic ester building block designed for advanced synthetic chemistry. This compound is valued for its unique molecular architecture, which combines a highly reactive pentafluorophenyl ester group with a tetrahydropyranyl-protected phenolic ether, making it a versatile intermediate for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as peptide coupling, polymer synthesis, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly for coupling reactions in peptide and small molecule API development.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the introduction of fluorinated aromatic systems is required.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the development of specialty fluorinated polymers with enhanced chemical resistance and thermal stability.
• Material Science Research: Employed in creating novel organic electronic materials, liquid crystals, and advanced coatings.
• Bioconjugation: Useful in labeling and modifying biomolecules (proteins, antibodies) due to the high reactivity of the pentafluorophenyl ester group under mild conditions.
• Chemical Biology Probes: Acts as a precursor for synthesizing activity-based probes and other tools for studying biological systems.

Basic Information

Product Name	Pentafluorophenyl 4-(Tetrahydropyran-4-Yloxy)Benzoate
CAS No.	930110-97-7
Molecular Formula	C18H14F5O4
Molecular Weight	398.30 g/mol
Synonyms	4-[(Oxan-4-yl)oxy]benzoic acid 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl 4-(tetrahydro-2H-pyran-4-yloxy)benzoate; 4-(Tetrahydropyran-4-yloxy)benzoic acid pentafluorophenyl ester; THP-protected pentafluorophenyl benzoate; PFP-THP-OBz; Benzoic acid, 4-[(tetrahydro-2H-pyran-4-yl)oxy]-, 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Every batch of Pentafluorophenyl 4-(Tetrahydropyran-4-Yloxy)Benzoate undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Our quality assurance protocols include identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to moisture and strong bases; ensure the container is kept sealed under an inert atmosphere for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.