Description

2-Fluoro-5-(Thiophen-2-Yl)Benzoic Acid is a high-purity fluorinated aromatic building block that serves as a critical intermediate in advanced organic synthesis. Its unique molecular architecture, combining a benzoic acid core with fluorine and thiophene substituents, enables precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring specific bioisosteric replacement or enhanced metabolic stability.

Application

• Key synthetic intermediate in the research and development of novel pharmaceutical candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Building block for constructing complex molecules in agrochemical research, contributing to the development of new herbicides and fungicides.
• Precursor in the synthesis of advanced organic electronic materials, such as semiconductors and light-emitting materials, where the thiophene-fluorobenzene unit is valuable.
• Versatile substrate for medicinal chemistry programs exploring structure-activity relationships (SAR) via Suzuki-Miyaura and other cross-coupling reactions.
• Used in academic and industrial R&D for creating specialized ligands, catalysts, and functional polymers.

Basic Information

Product Name	2-Fluoro-5-(Thiophen-2-Yl)Benzoic Acid
CAS No.	926205-45-0
Molecular Formula	C11H7FO2S
Molecular Weight	222.24 g/mol
Synonyms	5-(2-Thienyl)-2-fluorobenzoic Acid; 2-Fluoro-5-(2-thienyl)benzoic Acid; 2-Fluoro-5-(thiophen-2-yl)benzoic Acid; 2-Fluoro-5-thiophen-2-yl-benzoic Acid; Benzoic acid, 2-fluoro-5-(2-thienyl)-; 926205-45-0; 2-Fluoro-5-(2-thiophenyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Thiophen-2-Yl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.