Description

Opicapone is a potent, selective, and reversible catechol-O-methyltransferase (COMT) inhibitor used as an active pharmaceutical ingredient (API). It is a critical component in advanced adjunctive therapies for Parkinson's disease, enhancing the efficacy of levodopa by extending its duration of action. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing next-generation neurological treatments.

Application

• Pharmaceutical API: Primary use as the active ingredient in adjunctive therapy for Parkinson's disease, used in combination with levodopa and a dopa decarboxylase inhibitor.
• Neurological Drug Formulation: Incorporated into solid oral dosage forms, such as tablets and capsules, for the management of end-of-dose motor fluctuations.
• Clinical Research: Serves as a reference standard and key material in pharmacokinetic, pharmacodynamic, and bioavailability studies.
• Drug Development: Used in preclinical and clinical trials for investigating new therapeutic applications of COMT inhibition.
• Generic Drug Manufacturing: Essential for the production of generic versions of approved opicapone-based medications.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Opicapone
CAS No.	923287-50-7
Molecular Formula	C14H10ClN3O5
Molecular Weight	335.70 g/mol
Synonyms	BIA 9-1079; 2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide; (2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide); Opicapone BIA 9-1079; Ongentys (brand name)
EINECS	Contact for details

Quality Control

Our Opicapone is manufactured under strict quality management systems to meet the stringent requirements of the global pharmaceutical industry. Each batch is tested to ensure compliance with current pharmacopeial standards (e.g., USP, EP) and in-house specifications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results for identity, purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.