Description

1-(2,4-Difluorophenyl)Cyclopropanecarboxylic Acid is a high-value, multi-functional organic building block characterized by its unique cyclopropane ring and difluorophenyl moiety. This compound is essential for the synthesis of complex molecules, offering significant advantages in modulating the physicochemical and metabolic properties of target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms and rigid cyclopropane structure enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated aromatic components.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, catalysis studies, and the exploration of novel chemical spaces in medicinal and synthetic chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-(2,4-Difluorophenyl)Cyclopropanecarboxylic Acid
CAS No.	920501-68-4
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	1-(2,4-Difluorophenyl)cyclopropanecarboxylic acid; 2,4-Difluoro-α-(cyclopropylcarbonyl)benzene; Cyclopropanecarboxylic acid, 1-(2,4-difluorophenyl)-; 1-(2,4-Difluorophenyl)cyclopropane-1-carboxylic acid; 920501-68-4; 1-(2,4-Difluorophenyl)cyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Our 1-(2,4-Difluorophenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.