Description

Ro 25-6981 Hydrochloride is a highly selective and potent non-competitive antagonist of the NMDA receptor, specifically targeting the NR2B subunit. This specificity makes it a critical research tool for investigating neurological pathways related to learning, memory, and neuropathic pain. It is primarily utilized by pharmaceutical researchers and neuroscientists in academic, biotechnology, and pharmaceutical R&D settings for preclinical studies and drug discovery programs.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of NR2B-containing NMDA receptors in synaptic plasticity, long-term potentiation (LTP), and memory formation.
• Neuropharmacology: Used in in vitro and in vivo models to investigate mechanisms of neuroprotection, excitotoxicity, and neurological disorders such as Parkinson's and Alzheimer's disease.
• Pain Research: Employed in preclinical studies to explore the involvement of the NR2B subunit in the development and maintenance of chronic and neuropathic pain states.
• Psychiatric Disorder Models: Applied in research focused on depression, anxiety, and schizophrenia where glutamatergic system dysfunction is implicated.
• Drug Discovery & Development: Serves as a reference standard and lead compound for the design and screening of novel NR2B-selective NMDA receptor antagonists.
• Biochemical Assays: Used in receptor binding studies and functional assays to characterize compound interactions with the NMDA receptor complex.

Basic Information

Product Name	Ro 25-6981 Hydrochloride
CAS No.	919289-58-0
Molecular Formula	C₂₁H₂₃ClN₂O₂•HCl
Molecular Weight	415.34 g/mol
Synonyms	(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride; Ro 25-6981; Ro25-6981; Ro 25-6981 HCl; (R*,S*)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride; NMDA receptor antagonist Ro 25-6981; NR2B antagonist Ro 25-6981
EINECS	Contact for details

Quality Control

Our Ro 25-6981 Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.