Description

1,2,2,3,3-Pentafluorocyclopropane-1-Carboxylic Acid is a high-value, fluorinated cyclopropane derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group on a highly fluorinated three-membered ring, makes it an essential precursor for introducing fluorinated cyclopropane motifs into target molecules, which are prized for their ability to modulate lipophilicity, metabolic stability, and bioavailability. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents, where the fluorinated cyclopropane unit can enhance blood-brain barrier penetration and metabolic resistance.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can significantly improve the efficacy and environmental profile of the active compound.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers and specialty coatings that require specific chemical resistance, low surface energy, or unique optical properties.
• Ligand and Catalyst Development: Serves as a starting material for creating novel fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry Research: An important reagent for academic and industrial research focused on exploring new reactions and properties of heavily fluorinated small molecules and rings.

Basic Information

Product Name	1,2,2,3,3-Pentafluorocyclopropane-1-Carboxylic Acid
CAS No.	917951-65-6
Molecular Formula	C4HF5O2
Molecular Weight	176.04 g/mol
Synonyms	Pentafluorocyclopropanecarboxylic Acid; 1-Carboxypentafluorocyclopropane; Cyclopropanecarboxylic acid, 1,2,2,3,3-pentafluoro-; Perfluorocyclopropanecarboxylic Acid (common name); PFCPA (abbreviation); 1,2,2,3,3-Pentafluoro-1-cyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 1,2,2,3,3-Pentafluorocyclopropane-1-Carboxylic Acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency that meet the exacting standards of process chemistry and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.