Description

17S-Naltrexone Methobromide is a quaternary ammonium salt derivative of naltrexone, a potent opioid antagonist. This specific stereoisomer is of significant interest in advanced pharmacological research and development, particularly for its potential to create peripherally restricted opioid antagonists. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents targeting addiction, pain management, and gastrointestinal motility disorders without central nervous system effects.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation peripheral opioid receptor antagonists.
• Research Chemical: Used in preclinical studies to investigate the role of peripheral opioid receptors in various physiological and pathophysiological processes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop compounds with improved selectivity and pharmacokinetic profiles.
• Fine Chemical Synthesis: A specialized intermediate for contract research organizations (CROs) and custom synthesis operations.

Basic Information

Product Name	17S-Naltrexone Methobromide
CAS No.	916045-21-1
Molecular Formula	C21H26BrNO4
Molecular Weight	436.34 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one methobromide (17S); (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one methobromide; Naltrexone Methobromide (17S-isomer); Naltrexone Methyl Bromide; Quaternary Naltrexone Salt; 17S-MNTX; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 17S-Naltrexone Methobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.