Description

4-(Difluoromethoxy)-3-Hydroxybenzoic Acid is a fluorinated benzoic acid derivative characterized by its difluoromethoxy and phenolic hydroxyl functional groups. This unique molecular structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for synthetic organic chemistry. It is primarily utilized by research institutions and fine chemical manufacturers engaged in the development of novel active ingredients, particularly in the agrochemical and pharmaceutical sectors.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, especially those targeting metabolic and inflammatory pathways.
• Agrochemical Research: Serves as a precursor for developing new herbicides and plant growth regulators, leveraging the stability of the difluoromethoxy group.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel chelating ligands for catalytic applications.
• Material Science: A monomer or modifier for synthesizing specialty polymers with enhanced chemical resistance and specific optical properties.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry due to its reactive carboxylic acid and hydroxyl groups.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Hydroxybenzoic Acid
CAS No.	913985-07-6
Molecular Formula	C8H6F2O4
Molecular Weight	204.13 g/mol
Synonyms	3-Hydroxy-4-(difluoromethoxy)benzoic Acid; Benzoic acid, 4-(difluoromethoxy)-3-hydroxy-; 4-(Difluoromethoxy)-3-hydroxybenzoic acid; 913985-07-6; 3-Hydroxy-4-difluoromethoxybenzoic acid; 4-Difluoromethoxy-3-hydroxybenzoic acid
EINECS	Contact for details

Quality Control

Our production of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.