Description

Tideglusib CAS NO 912574-69-7 is a potent, selective, and irreversible inhibitor of glycogen synthase kinase-3 beta (GSK-3β). This small molecule is of significant interest in pharmaceutical research and development due to its potential neuroprotective and disease-modifying properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for neurodegenerative conditions, oncology, and metabolic disorders.

Application

• Neurodegenerative Disease Research: A key investigational compound for Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy (PSP) due to its inhibition of tau protein hyperphosphorylation.
• Oncology Research: Studied for its role in cancer cell proliferation and survival pathways, with potential applications in various cancer models.
• Metabolic Disorder Studies: Investigated for its effects on glucose metabolism and insulin signaling, relevant to type 2 diabetes research.
• Stem Cell Research: Used to modulate Wnt/β-catenin signaling pathways to influence cell fate and differentiation.
• Pharmacological Tool Compound: Serves as a standard and selective GSK-3β inhibitor in biochemical and cellular assay development.
• Preclinical Development: Employed in animal model studies to evaluate efficacy, pharmacokinetics, and safety profiles for potential drug candidates.

Basic Information

Product Name	Tideglusib
CAS No.	912574-69-7
Molecular Formula	C₁₇H₁₄N₄O₂S
Molecular Weight	338.38 g/mol
Synonyms	NP-031112; NP031112; GSK-3 Inhibitor IX; 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione; 1,2,4-Thiadiazolidine, 4-(phenylmethyl)-2-(1-naphthalenyl)-3,5-dioxo-; AR-A 014418 (related analog); Tideglusibum
EINECS	Contact for details

Quality Control

Our Tideglusib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Standard analytical techniques including HPLC, NMR, and MS are employed to verify the chemical structure and confirm the absence of significant contaminants. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.