Description

tert-Butyl 2-Chloro-4-Fluorobenzoate is a high-purity, synthetically valuable benzoate ester derivative. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis, enabling the construction of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the 2-chloro-4-fluorobenzoate moiety is required.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of novel organic materials, including liquid crystals and polymers with specific electronic properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	tert-Butyl 2-Chloro-4-Fluorobenzoate
CAS No.	911314-43-7
Molecular Formula	C11H12ClFO2
Molecular Weight	230.66 g/mol
Synonyms	2-Chloro-4-fluorobenzoic acid tert-butyl ester; tert-Butyl 2-chloro-4-fluorobenzoate; Benzoic acid, 2-chloro-4-fluoro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 2-chloro-4-fluorobenzoate; 2-Chloro-4-fluorobenzoic acid 1,1-dimethylethyl ester; t-Butyl 2-chloro-4-fluorobenzoate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-Chloro-4-Fluorobenzoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.