Description

Vasopressin Antagonist 1867 is a high-purity, non-peptide small molecule compound designed for selective antagonism of the vasopressin receptor. This compound is critical for advanced pharmacological research, particularly in studying cardiovascular regulation, fluid balance, and related endocrine pathways. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in the discovery and development of novel therapeutics for conditions like hyponatremia, heart failure, and polycystic kidney disease.

Application

• Pharmacological Research: A key reference standard and tool compound for in vitro and in vivo studies targeting vasopressin (AVP) V1a and V2 receptors.
• Drug Discovery & Development: Used in high-throughput screening (HTS), lead optimization, and mechanism-of-action studies for cardiovascular and renal disease pipelines.
• Biochemical Assays: Serves as a selective antagonist in receptor binding assays, functional cellular assays (e.g., cAMP modulation), and signal transduction pathway analysis.
• Preclinical Studies: Employed in animal models to investigate the therapeutic potential of vasopressin receptor blockade for managing water retention and blood pressure.
• Academic Research: Supports fundamental research in neuroendocrinology, physiology, and the pathophysiology of syndrome of inappropriate antidiuretic hormone secretion (SIADH).
• Reference Material: Acts as a certified standard for analytical method development, validation, and quality control in API synthesis for related drug candidates.

Basic Information

Product Name	Vasopressin Antagonist 1867
CAS No.	909391-88-4
Molecular Formula	C₂₃H₃₂ClN₅O₃S
Molecular Weight	494.05 g/mol
Synonyms	SR-121463B; Relcovaptan; SR121463; 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide; Vasopressin V1a/V2 Receptor Antagonist; Non-peptide vasopressin antagonist; AVP antagonist 1867
EINECS	Contact for details

Quality Control

Every batch of Vasopressin Antagonist 1867 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with relevant standards for research-grade chemicals. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and strength by validated methods such as HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.