Description

3-Des(Allylthio)Methyl-3-Chloromethyl Althiazide is a high-purity, advanced pharmaceutical intermediate and a key synthetic precursor in modern organic chemistry. This compound is critical for researchers and manufacturers developing novel therapeutic agents, particularly in the diuretic and antihypertensive drug classes. It is essential for pharmaceutical R&D laboratories, fine chemical synthesis facilities, and academic institutions focused on medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of thiazide and thiazide-like diuretic agents.
• Medicinal Chemistry Research: Used in the discovery and structure-activity relationship (SAR) studies of new cardiovascular drugs.
• Process Chemistry: Serves as a key starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Institutional R&D: Utilized in university and research institute projects exploring novel heterocyclic compounds and their biological activities.
• Custom Synthesis: A foundational substrate for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	3-Des(Allylthio)Methyl-3-Chloromethyl Althiazide
CAS No.	1824-47-1
Molecular Formula	C11H13ClN2O4S2
Molecular Weight	336.81 g/mol
Synonyms	3-(Chloromethyl)-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Chloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-Des(allylthio)methyl-3-chloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; Althiazide Intermediate; 3-Chloromethyl Althiazide Derivative
EINECS	Contact for details

Quality Control

Our 3-Des(Allylthio)Methyl-3-Chloromethyl Althiazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.