Description

6-Bromoamiloride is a potent and selective chemical probe, primarily recognized as a derivative of the classic sodium channel blocker amiloride. This compound is of significant value in biochemical and pharmacological research for its specific inhibitory activity. It is essential for researchers and developers in the pharmaceutical and life sciences sectors who are investigating ion channel physiology, structure-activity relationships, and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a key tool compound for studying epithelial sodium channels (ENaC) and acid-sensing ion channels (ASICs) in vitro.
• Pharmacology: Serves as a reference standard and a lead compound in the development of new diuretic or cardioprotective agents.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to design and synthesize novel amiloride analogs with improved potency or selectivity.
• Academic Research: Utilized in university and institutional labs for fundamental studies on ion transport mechanisms and cellular signaling pathways.
• Pharmaceutical Development: Acts as an intermediate or an active pharmaceutical ingredient (API) precursor in the synthesis of more complex drug candidates.

Basic Information

Product Name	6-Bromoamiloride
CAS No.	1136-94-3
Molecular Formula	C6H8BrClN7O
Molecular Weight	286.53 g/mol
Synonyms	6-Bromoamiloride; 3,5-Diamino-6-bromo-N-(diaminomethylene)pyrazine-2-carboxamide; 6-Bromoamiloride Hydrochloride (common salt form); 6-Br-Ami; Amiloride, 6-bromo-; N-Amidino-3,5-diamino-6-bromopyrazinecarboxamide; 6-Bromoamiloride HCl
EINECS	Contact for details

Quality Control

Our 6-Bromoamiloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.