Description

5-(N,n-Dimethyl)-Amiloride Hydrochloride is a high-purity, pharmacologically active derivative of amiloride, a well-known potassium-sparing diuretic agent. This compound serves as a crucial research-grade chemical intermediate and reference standard in the development and analysis of epithelial sodium channel (ENaC) blockers. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers for investigative and quality control purposes.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel amiloride analogs for drug discovery programs.
• Biochemical Research: Used as a reference standard and tool compound in studies targeting epithelial sodium channels (ENaC) in cardiovascular and renal physiology.
• Analytical Chemistry: Serves as a high-purity certified reference material (CRM) for method development, validation, and quality control in HPLC and LC-MS analysis.
• Academic Studies: Employed in university and institutional labs for pharmacological and mechanistic studies related to ion transport inhibition.

Basic Information

Product Name	5-(N,n-Dimethyl)-Amiloride Hydrochloride
CAS No.	1214-79-5
Molecular Formula	C8H12ClN7O·HCl
Molecular Weight	290.14 g/mol
Synonyms	5-(N,N-Dimethyl)amiloride HCl; 3,5-Diamino-6-chloro-N-(dimethylamino)pyrazinecarboxamide hydrochloride; 5-Dimethylamiloride hydrochloride; Amiloride dimethyl derivative hydrochloride; 6-Chloro-3,5-diamino-N-(dimethylamino)pyrazine-2-carboxamide hydrochloride; ENaC Blocker Derivative
EINECS	Contact for details

Quality Control

Our 5-(N,n-Dimethyl)-Amiloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.