Description

Methyclothiazide CAS NO 135-07-9 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the thiazide class of diuretics. It is a critical compound for the synthesis of antihypertensive and diuretic medications, valued for its consistent quality and reliable performance in complex formulations. This product is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the manufacture of antihypertensive and diuretic drugs.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Used in pharmacological studies to investigate renal function, electrolyte balance, and cardiovascular mechanisms.
• Formulation Development: A key component in the R&D of new solid dosage forms, such as tablets and capsules, for cardiovascular therapy.
• Chemical Intermediate: Employed in the synthesis of more complex thiazide derivatives and related pharmaceutical compounds.

Basic Information

Product Name	Methyclothiazide
CAS No.	135-07-9
Molecular Formula	C₉H₁₁Cl₂N₃O₄S₂
Molecular Weight	360.24 g/mol
Synonyms	Methyclothiazide; 6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Enduron; Aquatensen; 3,4-Dihydro-6-chloro-3-[(chloromethyl)-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methylchlorothiazide; NCI-C55818; Benzothiadiazine-7-sulfonamide derivative
EINECS	205-173-6

Quality Control

Our Methyclothiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) are provided with every shipment, confirming compliance with relevant pharmacopeial standards (e.g., USP, EP) and internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to prevent degradation from moisture and light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.