Description

Trichlormethiazide is a high-purity, potent thiazide diuretic API (Active Pharmaceutical Ingredient) with the CAS registry number 133-67-5. This compound is critical for the development and production of effective antihypertensive and diuretic medications, offering reliable therapeutic action. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical API: Core active ingredient in prescription medications for managing hypertension (high blood pressure).
• Diuretic Formulations: Used in drugs to treat edema associated with congestive heart failure, liver cirrhosis, and renal disorders.
• Drug Intermediate: Serves as a key synthetic intermediate in the production of more complex therapeutic agents.
• Research & Development: Utilized in pharmacological studies, bioavailability research, and new drug development projects.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, and other testing methods.
• Custom Synthesis: Basis for the custom synthesis of labeled compounds (e.g., deuterated or C14-labeled) for clinical trials and metabolic studies.

Basic Information

Product Name	Trichlormethiazide
CAS No.	133-67-5
Molecular Formula	C8H8Cl3N3O4S2
Molecular Weight	380.65 g/mol
Synonyms	6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Naqua; Metahydrin; Flomet; Trichlormethiazidum; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
EINECS	205-123-6

Quality Control

Our Trichlormethiazide is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including HPLC for assay and related substances, residual solvent analysis, and specific identification tests. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.