Description

5H-Amiloride CAS NO 1203-87-8 is a high-purity pharmaceutical intermediate and research chemical, recognized for its role as a precursor in the synthesis of Amiloride and related diuretic compounds. Its consistent quality and precise chemical structure are critical for ensuring the efficacy and safety of downstream active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical R&D laboratories, fine chemical synthesis, and manufacturers specializing in cardiovascular and diuretic medications.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of Amiloride hydrochloride, a potassium-sparing diuretic.
• Research & Development: Utilized in biochemical and pharmacological research to study epithelial sodium channel (ENaC) blockers and their mechanisms.
• Fine Chemical Synthesis: Serves as a starting material or intermediate for the preparation of novel analogs and derivatives with potential therapeutic activity.
• Reference Standard: Used as an analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Academic Studies: Employed in university and institutional research for studying ion transport and diuretic agents.

Basic Information

Product Name	5H-Amiloride
CAS No.	1203-87-8
Molecular Formula	C6H8ClN7O
Molecular Weight	229.63 g/mol
Synonyms	3,5-Diamino-6-chloropyrazine-2-carboxamide; 6-Chloro-3,5-diaminopyrazine-2-carboxamide; Amiloride Intermediate; Amiloride Pyrazine Carboxamide; 5H-Pyrazino[2,3-d]pyrimidine-2,7-diamine, 6-chloro-; NSC 141140; 6-Chloro-3,5-diamino-N-carbamoylpyrazine
EINECS	Contact for details

Quality Control

Our 5H-Amiloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and rigorous tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and relevant pharmacopeial guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.