Description

Bemetizide CAS NO 1824-52-8 is a high-purity pharmaceutical intermediate belonging to the thiazide diuretic class. This compound is critical for the research and development of novel antihypertensive and diuretic agents, offering a reliable building block for medicinal chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of thiazide and thiazide-like diuretic drugs.
• Active Pharmaceutical Ingredient (API) Research: Used in R&D for developing new antihypertensive medications and studying structure-activity relationships (SAR).
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting, optimization, and scale-up studies for efficient API manufacturing processes.
• Biochemical Research: Used in pharmacological studies to investigate diuretic mechanisms and renal electrolyte transport.

Basic Information

Product Name	Bemetizide
CAS No.	1824-52-8
Molecular Formula	C15H16ClN3O4S2
Molecular Weight	425.89 g/mol
Synonyms	Bemetizide; 3-(Benzylsulfonyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide; 6-Chloro-3,4-dihydro-3-(phenylmethyl)sulfonyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(phenylmethylsulfonyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Bemetizidum; Bemetizid; NSC 113884
EINECS	217-356-9

Quality Control

Our Bemetizide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets stringent specifications suitable for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.