Description

4-(Difluoromethoxy)-3-Nitrobenzoic Acid is a specialized aromatic carboxylic acid derivative featuring both difluoromethoxy and nitro substituents, making it a valuable multifunctional building block in advanced chemical synthesis. Its unique structure provides critical reactivity for constructing complex molecules where electronic and steric properties are finely tuned. This intermediate is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide bond formations to introduce nitro and carboxylic acid functionalities.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and drug discovery programs targeting various disease pathways.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Nitrobenzoic Acid
CAS No.	906747-90-8
Molecular Formula	C8H5F2NO5
Molecular Weight	233.13 g/mol
Synonyms	3-Nitro-4-(difluoromethoxy)benzoic Acid; Benzoic acid, 4-(difluoromethoxy)-3-nitro-; 4-(Difluoromethoxy)-3-nitro-benzoic acid; 906747-90-8; 4-Difluoromethoxy-3-nitrobenzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Nitrobenzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.