Description

Custirsen CAS NO 903916-27-8 is a second-generation antisense oligonucleotide designed to inhibit the production of clusterin, a cytoprotective chaperone protein. This compound is of significant interest for its potential role in modulating treatment resistance in oncology. It is primarily utilized in advanced pharmaceutical research and development, particularly in the formulation of novel therapeutic agents targeting prostate cancer and other solid tumors.

Application

• Oncological Research: Key investigational component in clinical studies for castration-resistant prostate cancer (CRPC) and non-small cell lung cancer (NSCLC).
• Drug Resistance Modulation: Used to study and potentially overcome chemotherapy-induced resistance by inhibiting clusterin expression.
• Pharmaceutical Intermediate: Serves as a critical active pharmaceutical ingredient (API) in the development of targeted antisense therapies.
• Preclinical Development: Employed in in-vitro and in-vivo models to evaluate efficacy, pharmacokinetics, and mechanism of action.
• Combination Therapy Studies: Investigated in conjunction with standard chemotherapeutic agents like docetaxel to enhance apoptotic response.
• Molecular Biology Research: Tool compound for studying the role of clusterin in cell stress, apoptosis, and tumor progression pathways.

Basic Information

Item	Detail
Product Name	Custirsen
CAS No.	903916-27-8
Molecular Formula	C234H295N73O122P20S20
Molecular Weight	6934.0 g/mol (approximate)
Synonyms	OGX-011; ISIS 112989; CX-011; Custirsen sodium; Apatorsen; Clusterin inhibitor OGX-011; Antisense oligonucleotide OGX-011; OGX-011 sodium salt
EINECS	Contact for details

Quality Control

Our Custirsen is manufactured under strict cGMP guidelines to ensure the highest standards of purity and consistency for research and pharmaceutical use. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as identity, purity, and impurity profile. We ensure compliance with relevant ICH guidelines for oligonucleotide therapeutics.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (Ion-Exchange HPLC)	≥ 90.0% full-length oligonucleotide
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 10 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.