Description

Vancomycin, 56-Methyl- is a chemically modified derivative of the glycopeptide antibiotic vancomycin, characterized by a methyl group substitution at the 56-position. This structural modification is of significant interest in pharmaceutical research for exploring enhanced antibacterial activity, altered pharmacokinetic properties, or reduced potential for resistance development. It serves as a critical advanced pharmaceutical intermediate and reference standard for researchers and developers in the fields of antibiotic discovery, medicinal chemistry, and analytical method development.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel vancomycin analogs for evaluating structure-activity relationships (SAR).
• Antibiotic Discovery Programs: Used in biological assays to study the impact of specific methyl modifications on antibacterial potency and spectrum.
• Medicinal Chemistry Studies: A building block for creating semi-synthetic derivatives aimed at overcoming vancomycin-resistant bacterial strains (e.g., VRE, VRSA).
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, or NMR analysis in quality control and method validation.
• Biochemical Research: Tool compound for investigating the molecular mechanisms of glycopeptide antibiotic action and bacterial cell wall synthesis inhibition.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for next-generation antibiotic candidates.

Basic Information

Product Name	Vancomycin, 56-Methyl-
CAS No.	99759-13-4
Molecular Formula	C67H77Cl2N9O24
Molecular Weight	1449.27 g/mol
Synonyms	56-Methylvancomycin; Methylvancomycin; Vancomycin methyl derivative; 56-O-Methylvancomycin; (56-Methyl)vancomycin; Antibiotic A 35512B derivative; Glycopeptide antibiotic derivative; Vancomycin analog
EINECS	Contact for details

Quality Control

Our Vancomycin, 56-Methyl- is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Quality is assured through a comprehensive battery of analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) providing purity, identity confirmation, and impurity profile is supplied with each batch. We adhere to rigorous internal standards to meet the specific requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.