Description

Rotigotine is a non-ergoline dopamine agonist with high selectivity for dopamine D2 receptors. This compound is of significant commercial and therapeutic importance as the active pharmaceutical ingredient (API) in transdermal patches for the treatment of Parkinson's disease and Restless Legs Syndrome (RLS). It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development of innovative neurological therapies. Our supply of Rotigotine CAS NO 99755-59-6 is characterized by stringent quality control to ensure consistency and reliability for critical formulation processes.

Application

• Pharmaceutical API: Primary use as the active ingredient in continuous dopaminergic delivery systems, specifically transdermal patches.
• Neurological Disorder Treatment: Formulation for managing symptoms of early and advanced-stage Parkinson's disease.
• Restless Legs Syndrome (RLS) Therapy: Key component in long-term treatment formulations for moderate-to-severe primary RLS.
• Drug Delivery Research: Used in R&D for studying novel transdermal and sustained-release delivery mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Preclinical & Clinical Studies: Utilized in pharmacological research to investigate dopaminergic pathways and therapeutic efficacy.

Basic Information

Product Name	Rotigotine
CAS No.	99755-59-6
Molecular Formula	C19H25NOS
Molecular Weight	315.47 g/mol
Synonyms	(-)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol; (6R)-6-(Propyl(2-thiophen-2-ylethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol; N-0923; SPM 962; DAS-980; Rotigotine Hydrochloride (salt form); Rotigotine free base
EINECS	Contact for details

Quality Control

Our Rotigotine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling to ensure it meets exacting pharmaceutical standards. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support compliance with ICH Q7 guidelines and relevant pharmacopoeial requirements (e.g., USP, EP) for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.