Description

S(+)-Doi Hydrochloride is a high-purity chiral compound, specifically the S-enantiomer of the potent and selective 5-HT2A receptor agonist DOI. This enantiomeric purity is critical for precise pharmacological research and development. It serves as an indispensable reference standard and active pharmaceutical ingredient (API) intermediate for neuroscientists and pharmaceutical developers. Its primary utility is in advanced neuropharmacology studies, receptor binding assays, and the development of novel central nervous system (CNS) therapeutics.

Application

• Pharmacological Research: As a selective agonist for studying 5-HT2A and 5-HT2C serotonin receptor subtypes in vitro and in vivo.
• Neuroscience Reference Standard: Used for calibrating analytical equipment (HPLC, LC-MS) and validating assay methods in academic and industrial labs.
• Drug Discovery & Development: A key intermediate in the synthesis pathway for novel psychoactive substances and CNS-targeting drug candidates.
• Biochemical Assays: Employed in receptor binding, functional selectivity, and signal transduction studies to understand serotonin system dynamics.
• Toxicology & Safety Pharmacology: Used to establish dose-response curves and study the effects of 5-HT2A receptor activation.
• Chemical Synthesis: Serves as a chiral building block for the preparation of more complex, receptor-targeting molecules.

Basic Information

Product Name	S(+)-Doi Hydrochloride
CAS No.	99665-05-1
Molecular Formula	C11H16ClNO · HCl
Molecular Weight	250.16 g/mol (for hydrochloride salt)
Synonyms	(+)-DOI Hydrochloride; (S)-DOI HCl; (S)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane Hydrochloride; S(+)-2,5-Dimethoxy-4-iodoamphetamine Hydrochloride; (S)-2,5-Dimethoxy-4-iodoamphetamine HCl; S-DOI HCl; R(-)-DOI Hydrochloride enantiomer; 5-HT2A Receptor Agonist
EINECS	Contact for details

Quality Control

Every batch of S(+)-Doi Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and development. Certificates of Analysis (COA) detailing HPLC purity, chiral purity, residual solvent analysis, and other critical parameters are available for each lot. Our quality commitment supports compliance with relevant guidelines for reference standards and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.