Description

H-Glu-Amc CAS NO 98516-76-8 is a specialized fluorogenic peptide substrate, widely recognized for its critical role in enzymatic activity assays. This compound is essential for researchers and quality control laboratories requiring precise and sensitive detection of protease activity. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic industries for high-throughput screening and biochemical research.

Application

• Protease Activity Assays: As a fluorogenic substrate for quantifying the activity of glutamyl endopeptidases and related proteolytic enzymes.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize novel protease inhibitors.
• Biochemical Research: A key tool for studying enzyme kinetics, specificity, and mechanism of action in vitro.
• Diagnostic Kit Development: Incorporated into diagnostic assays for detecting specific protease biomarkers associated with diseases.
• Quality Control in Biologics: Employed to monitor and validate the purity and activity of enzyme-based therapeutic products during manufacturing.

Basic Information

Product Name	H-Glu-Amc
CAS No.	98516-76-8
Molecular Formula	C16H19N3O5
Molecular Weight	333.34 g/mol
Synonyms	L-Glutamic acid 7-amido-4-methylcoumarin; Glutamic Acid 7-Amido-4-methylcoumarin; Glu-AMC; H-Glu-AMC; L-Glu-AMC; Substrate for Glu-specific proteases; 7-Amido-4-methylcoumarin conjugate of L-Glutamic acid; Fluorogenic substrate V
EINECS	Contact for details

Quality Control

Our H-Glu-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.