Description

2-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated organic building block characterized by its cinnamic acid backbone substituted with a trifluoromethyl group. This compound matters for its unique combination of aromaticity and the electron-withdrawing properties of the fluorine atoms, making it a versatile intermediate in advanced synthesis. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Heck reactions, and as a precursor for other fluorinated fine chemicals and complex molecules.

Basic Information

Product Name	2-(Trifluoromethyl)Cinnamic Acid
CAS No.	98386-81-3
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	(E)-3-[2-(Trifluoromethyl)phenyl]prop-2-enoic acid; 2-(Trifluoromethyl)cinnamic acid; α-(Trifluoromethyl)cinnamic acid; (E)-2-(Trifluoromethyl)cinnamic acid; 3-(2-(Trifluoromethyl)phenyl)acrylic acid; trans-2-(Trifluoromethyl)cinnamic acid; 2-Trifluoromethylcinnamic Acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Cinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.