Description

Ethyl 2,4,5-Trifluorobenzoylacetate is a versatile fluorinated organic building block, specifically an ester derivative of a trifluorobenzoylacetate. Its value lies in its role as a key synthetic intermediate for constructing complex molecules containing the biologically relevant 2,4,5-trifluorophenyl moiety. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity and target binding.
• Material Science Research: Serves as a monomer or building block for developing novel fluorinated polymers and liquid crystals with unique thermal and optical properties.
• Chemical Synthesis: Employed in organic synthesis for Friedel-Crafts acylation, condensation reactions, and the preparation of heterocyclic compounds like pyrazoles and isoxazoles.
• Fluorine Chemistry: A valuable reagent for introducing the 2,4,5-trifluorobenzoyl group into complex molecular architectures in medicinal and process chemistry.

Basic Information

Product Name	Ethyl 2,4,5-Trifluorobenzoylacetate
CAS No.	98349-24-7
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	Ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate; 2,4,5-Trifluorobenzoylacetic Acid Ethyl Ester; 3-(2,4,5-Trifluorobenzoyl)propanoic Acid Ethyl Ester; Acetic acid, 2,4,5-trifluorobenzoyl-, ethyl ester; Ethyl (2,4,5-trifluorobenzoyl)acetate; 98349-24-7; Ethyl 3-(2,4,5-trifluorophenyl)-3-oxopropanoate
EINECS	Contact for details

Quality Control

Our Ethyl 2,4,5-Trifluorobenzoylacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.