Description

Chloroethylclonidine Dihydrochloride is a high-purity, research-grade chemical compound primarily utilized as a selective α2-adrenoceptor antagonist in pharmacological studies. This specificity makes it a critical tool for researchers investigating adrenergic receptor mechanisms, signal transduction pathways, and cardiovascular physiology. It is essential for pharmaceutical R&D, academic research, and contract research organizations (CROs) focused on neuropharmacology and autonomic nervous system drug discovery.

Application

• Pharmacological Research: As a selective antagonist for characterizing α2-adrenergic receptor subtypes in vitro and in vivo studies.
• Neurochemical Studies: Investigating the role of adrenoceptors in neurotransmitter release and synaptic transmission within the central and peripheral nervous systems.
• Cardiovascular Research: Studying the modulation of blood pressure, heart rate, and vascular tone by the sympathetic nervous system.
• Drug Discovery & Development: Serving as a reference standard and pharmacological tool in screening assays for novel therapeutics targeting adrenergic pathways.
• Academic & Institutional Research: Used in university and government laboratory settings for fundamental biomedical research and teaching.
• Biochemical Assay Development: Employed in the validation and calibration of receptor binding assays and functional cellular tests.

Basic Information

Product Name	Chloroethylclonidine Dihydrochloride
CAS No.	98086-36-3
Molecular Formula	C13H16Cl3N3·2HCl
Molecular Weight	402.97 g/mol (Free base: 312.65 g/mol)
Synonyms	Chloroethylclonidine 2HCl; CEC dihydrochloride; 2-(2-Chloroethyl)-1,3-dihydro-2H-imidazo[2,1-b]quinazolin-5-amine dihydrochloride; N-(2-Chloroethyl)clonidine dihydrochloride; α2-Adrenoceptor antagonist CEC; L-659,066 (dihydrochloride); Irreversible α2-adrenergic antagonist
EINECS	Contact for details

Quality Control

Our Chloroethylclonidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.