Description

Interferon-γ-1A is a potent, naturally occurring cytokine with significant immunomodulatory and antiviral properties. This high-purity recombinant protein is critical for advanced biomedical research and therapeutic development, offering a reliable tool for studying immune system regulation and cellular signaling pathways. It is essential for pharmaceutical manufacturers, biotechnology R&D laboratories, and academic institutions focused on immunology, oncology, and infectious disease research.

Application

• Biopharmaceutical Development: A key active pharmaceutical ingredient (API) or critical raw material in the formulation of immunotherapies and treatments for chronic granulomatous disease and osteopetrosis.
• Immunology Research: Used to activate macrophages, enhance antigen presentation, and modulate Th1 immune responses in in vitro and in vivo studies.
• Cell Culture & Virology: Employed to induce an antiviral state in cell lines and to study host-pathogen interactions.
• Diagnostic Reagent Production: Serves as a standard or calibrator in the manufacture of ELISA kits and other immunoassays for cytokine detection.
• Cancer Research: Investigated for its anti-proliferative and immunostimulatory effects in various oncology research models.
• Process Development & Quality Control: Used as a reference standard in the analytical testing and validation of biopharmaceutical manufacturing processes.

Basic Information

Product Name	Interferon-γ-1A
CAS No.	98059-18-8
Molecular Formula	C~860~H~1353~N~229~O~255~S~9~
Molecular Weight	Approx. 19,300 Da (monomer)
Synonyms	Interferon γ-1a; IFN-γ-1a; Immune Interferon; rIFN-γ; Actimmune (trade name); Gamma Interferon; Type II Interferon; IFNG; HuIFN-gamma
EINECS	Contact for details

Quality Control

Our Interferon-γ-1A is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure identity, purity, potency, and safety. Each batch is tested against stringent specifications, including SDS-PAGE, RP-HPLC, SEC-HPLC, and bioactivity assays. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided and available upon request, supporting compliance with cGMP guidelines for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, low-humidity conditions.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (SDS-PAGE)	Consistent with reference standard
Purity (RP-HPLC)	≥ 98.0%
Purity (SEC-HPLC)	≥ 95.0% (monomer)
Potency (Cell-based assay)	≥ 1.0 x 10^7 IU/mg
Endotoxin	< 1.0 EU/μg
Moisture Content (KF)	≤ 3.0%
Biological Activity	Induces MHC class II expression on target cells

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.