Description

Monophosphoryl 3-Deacyl Lipid A is a synthetic, detoxified derivative of bacterial lipopolysaccharide (LPS) endotoxin, designed to retain potent immunostimulatory activity while significantly reducing toxicity. This compound is a critical research tool and a promising adjuvant candidate for vaccine development, offering a refined mechanism to modulate innate immune responses. It is essential for scientists and manufacturers in the fields of immunology, vaccine research, and advanced pharmaceutical development.

Application

• Vaccine Adjuvant Research: A key component in preclinical and clinical studies for developing novel vaccine formulations against infectious diseases and cancer.
• Immunology & Cell Signaling Studies: Used to investigate Toll-like receptor 4 (TLR4) signaling pathways and macrophage activation in vitro and in vivo.
• Therapeutic Agent Development: Serves as a base structure for developing immunomodulators targeting sepsis, autoimmune disorders, and allergy.
• Quality Control & Standardization: Acts as a reference standard for the analysis and quality control of lipid A-based products and adjuvants.
• Drug Delivery Systems: Incorporated into liposomal or nanoparticle formulations to enhance targeted immune stimulation.

Basic Information

Product Name	Monophosphoryl 3-Deacyl Lipid A
CAS No.	1699735-79-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-Deacyl Monophosphoryl Lipid A; 3D-MPL; Monophosphoryl Lipid A 3-Deacyl; TLR4 Agonist 3D-MPL; Synthetic Lipid A Derivative; Detoxified Lipid A; GLA; Glucopyranosyl Lipid Adjuvant (related class)
EINECS	Contact for details

Quality Control

Our Monophosphoryl 3-Deacyl Lipid A is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LAL assay for endotoxin activity, and structural confirmation by mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and biological activity are provided to ensure compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere when possible to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Endotoxin Activity (LAL)	< 1.0 EU/μg
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.