Description

n-(3-Hydroxybutanoyl)-L-Homoserine Lactone is a specialized chiral lactone derivative that serves as a key signaling molecule and synthetic intermediate in advanced biochemical research. Its precise stereochemistry and functional groups make it a critical building block for studying and modulating quorum-sensing pathways in microbial systems. This high-purity compound is essential for researchers and developers in the pharmaceutical, agrochemical, and life science sectors who require reliable, well-characterized materials for target validation and novel bioactive compound synthesis.

Application

• Quorum Sensing Research: As a structural analog of natural autoinducers, it is used to investigate and manipulate bacterial cell-to-cell communication for anti-virulence drug discovery.
• Pharmaceutical Intermediates: Serves as a chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly those targeting bacterial infections.
• Agrochemical Development: Employed in R&D for creating next-generation crop protection agents that disrupt pathogenic bacterial signaling without promoting antibiotic resistance.
• Microbial Physiology Studies: A tool compound for probing the regulatory mechanisms of biofilm formation, virulence factor production, and other group behaviors in bacteria.
• Biochemical Reagent: Used in enzymatic assays and as a substrate or inhibitor to study the function of lactonases and other modifying enzymes.
• Academic & Institutional Research: A key material for universities and research institutes conducting fundamental studies in microbiology, chemical biology, and synthetic chemistry.

Basic Information

Product Name	n-(3-Hydroxybutanoyl)-L-Homoserine Lactone
CAS No.	1325550-06-8
Molecular Formula	C9H15NO5
Molecular Weight	217.22 g/mol
Synonyms	(S)-3-Hydroxybutanoyl-L-homoserine lactone; N-(3-Hydroxybutyryl)-L-homoserine lactone; 3-Hydroxy-C4-HSL; 3-OH-C4-AHL; N-3-Hydroxybutanoylhomoserine lactone; BHL; Autoinducer analog; N-(3-Hydroxybutanoyl)-L-homoserine lactone; Quorum sensing molecule C4 derivative
EINECS	Contact for details

Quality Control

Every batch of n-(3-Hydroxybutanoyl)-L-Homoserine Lactone is manufactured and tested under a strict quality management system to ensure identity, purity, and consistency. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.