Description

6'-o-(6-Aminocaproyl)-4'-o-Monophosphoryl Lipid A is a synthetic derivative of monophosphoryl lipid A (MPLA), a potent yet less toxic TLR4 agonist. This compound is engineered to enhance solubility and facilitate conjugation, making it a critical intermediate in advanced vaccine adjuvant and immunotherapeutic development. It is primarily utilized by pharmaceutical R&D teams and biotech companies focused on creating next-generation vaccines, cancer immunotherapies, and targeted drug delivery systems.

Application

• Vaccine Adjuvant Conjugation: Serves as a key building block for covalently attaching MPLA to antigens, proteins, or carriers to create novel, self-adjuvanting vaccine constructs.
• Immunotherapy Development: Used in the research and production of immunomodulatory agents designed to stimulate specific immune responses against cancers or chronic infections.
• Drug Delivery Systems: Incorporated into liposomal or nanoparticle formulations to target the immune system and enhance the efficacy of encapsulated drugs.
• TLR4 Pathway Research: A vital tool in immunological studies to investigate Toll-like receptor 4 signaling mechanisms and innate immune activation.
• Bioconjugation & Linker Chemistry: The exposed aminocaproyl linker arm allows for straightforward coupling via amine-reactive chemistry (e.g., NHS esters, isocyanates) to various biomolecules.
• GMP-grade Pharmaceutical Manufacturing: Supports the cGMP-compliant production of clinical-stage and commercial immunotherapeutic products.

Basic Information

Product Name	6'-o-(6-Aminocaproyl)-4'-o-Monophosphoryl Lipid A
CAS No.	144710-90-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6'-O-(6-Aminocaproyl)-4'-O-monophosphoryl Lipid A; Aminocaproyl-MPLA; MPLA-6'-NH2; TLR4 Agonist Conjugate Intermediate; (6'-O-(6-Aminohexanoyl)-4'-O-monophosphoryl Lipid A); Synthetic Lipid A Derivative; Adjuvant Conjugation Intermediate; Monophosphoryl Lipid A-aminocaproic acid conjugate
EINECS	Contact for details

Quality Control

Our 6'-o-(6-Aminocaproyl)-4'-o-Monophosphoryl Lipid A is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and LAL testing for endotoxin levels where specified. Certificates of Analysis (COA) detailing all specifications are provided. We support development from research to GMP-grade material, ensuring compliance with relevant regulatory frameworks for advanced therapeutic medicinal products (ATMPs).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Endotoxin (LAL)	<10 EU/mg (or per customer requirement)
Solubility	Soluble in chloroform, DMSO, ethanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.