Description

Peginterferon Alfa-2B CAS NO 215647-85-1 is a long-acting, polyethylene glycol-conjugated form of recombinant interferon alfa-2b, designed to extend its therapeutic half-life and reduce dosing frequency. This modification is critical for enhancing patient compliance and improving the efficacy profile in chronic treatment regimens. It is a vital active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and advanced research institutions developing therapies for viral infections and certain cancers.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of chronic hepatitis B and C.
• Oncology Therapeutics: Investigational and approved use in the management of certain cancers, including melanoma and renal cell carcinoma.
• Clinical Research: Serves as a key reagent in preclinical and clinical studies exploring new antiviral and immunomodulatory therapies.
• Biosimilar Development: Used as a reference standard or starting material in the development and analytical testing of biosimilar products.
• Advanced Drug Delivery Systems: Research into novel formulations and delivery mechanisms leveraging its pegylated structure.

Basic Information

Product Name	Peginterferon Alfa-2B
CAS No.	215647-85-1
Molecular Formula	C860H1353N229O255S9 (approx., varies with PEGylation)
Molecular Weight	> 31,000 Da (Protein conjugate, exact MW varies with PEG chain length and number)
Synonyms	PEG-IFN alfa-2b; Pegylated Interferon Alfa-2b; PEG Intron® (Brand Name); Peginterferon alfa-2b; Interferon alfa-2b PEG conjugate; Polyethylene glycol-modified interferon alfa-2b; Recombinant pegylated interferon α-2b; IFN α-2b-PEG
EINECS	Contact for details

Quality Control

Our Peginterferon Alfa-2B is manufactured under strict cGMP guidelines to ensure the highest standards of purity, potency, and consistency. Quality is assured through a comprehensive battery of tests including biological activity (antiviral assay), purity and impurity profile (SEC-HPLC, RP-HPLC), PEG content analysis, and sterility and endotoxin testing. Certificates of Analysis (COA) detailing all release specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and must be handled under controlled conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/Peptide Map)	Conforms to reference standard
Biological Activity	> 1.0 x 108 IU/mg
Assay (Protein Content)	90.0% - 110.0% of label claim
Purity (SEC-HPLC)	> 95.0% Monomer
Related Proteins (HPLC)	< 5.0% total
PEG Content	As per target specification
Endotoxins	< 10 EU/mg
Sterility	Sterile
Moisture (K.F. Titration)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.