Description

Mpla (Synthetic) Sterile Solution is a high-purity, endotoxin-free synthetic derivative of monophosphoryl lipid A (MPL), a potent immunostimulant and vaccine adjuvant. This sterile-filtered solution is designed for critical research and development applications where consistency, safety, and biological activity are paramount. It is an essential reagent for immunologists and pharmaceutical developers working on next-generation vaccines, cancer immunotherapies, and studies of innate immune signaling via the TLR4 pathway.

Application

• Vaccine Adjuvant Development: Used as a key component in preclinical and clinical research for enhancing the immunogenicity and efficacy of subunit, recombinant, and conjugate vaccines.
• Immunology & Cell Biology Research: Serves as a precise tool for activating TLR4 (Toll-like receptor 4) signaling in vitro and in vivo studies of innate immunity and inflammation.
• Cancer Immunotherapy: Investigated as an immunomodulatory agent in therapeutic cancer vaccines and combination therapies to stimulate anti-tumor immune responses.
• Pharmaceutical Formulation: Incorporated into liposomal, nanoparticle, or other delivery systems for advanced drug and vaccine formulations requiring a defined, synthetic adjuvant.
• Biologics & Biosimilar Characterization: Employed as a reference standard or challenge agent in assays to characterize biological products and their interaction with the immune system.

Basic Information

Product Name	Mpla (Synthetic) Sterile Solution
CAS No.	1246298-63-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Synthetic Monophosphoryl Lipid A; MPL; MPLA; GLA; Glucopyranosyl Lipid Adjuvant; TLR4 Agonist; Phosphorylated Hexaacyl Disaccharide; 3-O-Desacyl-4'-monophosphoryl lipid A; Vaccine Adjuvant
EINECS	Contact for details

Quality Control

Our Mpla (Synthetic) Sterile Solution is manufactured under stringent conditions to ensure the highest standards of purity and biological consistency. Each batch is subjected to a comprehensive battery of analytical tests, including identity confirmation, purity assay, endotoxin level quantification, and sterility testing. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product should be handled using aseptic techniques appropriate for sterile solutions.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Endotoxin (LAL)	< 0.1 EU/µg
Sterility (Membrane Filtration)	Sterile
pH	6.5 - 7.5
Osmolality	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.