Description

Di[3-Deoxy-D-Manno-Octulosonyl]-Lipid A (Ammonium Salt) is a highly purified, synthetic derivative of lipid A, a key component of bacterial lipopolysaccharides (LPS). This compound is critically important as a potent and well-defined Toll-like receptor 4 (TLR4) agonist for advanced immunological research and adjuvant development. It is essential for scientists and manufacturers in the pharmaceutical and biotechnology sectors who require a reliable, high-purity standard for vaccine research, immunology studies, and the development of novel immunotherapies.

Application

• Vaccine Adjuvant Research: As a defined TLR4 agonist for investigating and developing next-generation vaccine formulations.
• Immunology & Cell Signaling Studies: A critical tool for studying innate immune responses, macrophage activation, and cytokine production pathways.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for LPS and endotoxin testing.
• Drug Discovery Screening: Employed in assays to identify novel modulators of the TLR4 signaling pathway.
• Cancer Immunotherapy Research: Investigated for its potential to stimulate anti-tumor immune responses in preclinical models.
• Inflammation Research: Used to model and study inflammatory diseases and septic shock mechanisms.

Basic Information

Item	Detail
Product Name	Di[3-Deoxy-D-Manno-Octulosonyl]-Lipid A (Ammonium Salt)
CAS No.	1246298-62-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ammonium Salt of Di[3-Deoxy-D-Manno-Octulosonyl]-Lipid A; Synthetic Lipid A (Ammonium Salt); TLR4 Agonist (Ammonium Salt); KDO2-Lipid A, Ammonium Salt; 3-Deoxy-D-manno-oct-2-ulosonic acid Lipid A derivative; Defined TLR4 Ligand; LPS Mimetic (Ammonium Salt)
EINECS	Contact for details

Quality Control

Every batch of Di[3-Deoxy-D-Manno-Octulosonyl]-Lipid A (Ammonium Salt) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our quality control protocols are designed to meet the exacting standards of pharmaceutical research, ensuring batch-to-batch consistency, identity, purity, and biological activity. A detailed Certificate of Analysis (COA) providing results for identity (NMR, MS), purity (HPLC), endotoxin levels, and biological potency is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 1.0 EU/mg
Biological Activity (Cell-Based Assay)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.