Description

2-Difluoromethoxy-Benzoic Acid Methyl Ester is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of the difluoromethoxy group, which can profoundly influence the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy moiety can enhance biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a fluorinated precursor in the synthesis of specialty chemicals for electronic displays, leveraging its ability to modify dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials due to its electron-withdrawing characteristics and potential for fine-tuning HOMO/LUMO levels.
• Chemical Research & Development: A versatile building block for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	2-Difluoromethoxy-Benzoic Acid Methyl Ester
CAS No.	97914-53-9
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	Methyl 2-(difluoromethoxy)benzoate; Benzoic acid, 2-(difluoromethoxy)-, methyl ester; 2-(Difluoromethoxy)benzoic acid methyl ester; Methyl o-(difluoromethoxy)benzoate; Methyl 2-difluoromethoxybenzoate; DFMB Methyl Ester; 97914-53-9
EINECS	Contact for details

Quality Control

Our production of 2-Difluoromethoxy-Benzoic Acid Methyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed against comprehensive specifications, including identity confirmation, assay, and impurity profiling. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.