Description

4-Amino-3-Bromo-5-Trifluoromethyl-Benzoic Acid is a high-value, multi-functional aromatic building block distinguished by its unique trifluoromethyl and halogen substitution pattern. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure imparts desirable metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Chemical Research: A versatile reagent for Suzuki, Buchwald-Hartwig, and other cross-coupling reactions to create complex, fluorinated biaryl structures.
• Dye and Pigment Intermediate: Used in the synthesis of specialized fluorinated colorants and imaging agents.

Basic Information

Product Name	4-Amino-3-Bromo-5-Trifluoromethyl-Benzoic Acid
CAS No.	97776-05-1
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	3-Bromo-4-amino-5-(trifluoromethyl)benzoic acid; Benzoic acid, 4-amino-3-bromo-5-(trifluoromethyl)-; 4-Amino-3-bromo-α,α,α-trifluoro-m-toluic acid; 5-Trifluoromethyl-4-amino-3-bromobenzoic acid; 3-Bromo-4-amino-α,α,α-trifluoro-m-toluic acid; 4-Amino-3-bromo-5-trifluoromethylbenzoic acid; 97776-05-1
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Bromo-5-Trifluoromethyl-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant global regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.