Description

3-Maleimido-4-Methyl-6,7-Methylenedioxycoumarin is a specialized bifunctional coumarin derivative that serves as a versatile fluorescent labeling and cross-linking reagent. Its core value lies in the maleimide group's ability to form stable thioether bonds with sulfhydryl groups, combined with the coumarin moiety's excellent photophysical properties. This compound is essential for researchers and manufacturers in bioconjugation, proteomics, and advanced materials science, enabling the development of fluorescent probes, antibody-drug conjugates (ADCs), and polymer cross-linking.

Application

• Bioconjugation & Fluorescent Labeling: Covalent attachment to proteins, peptides, and antibodies via thiol-maleimide chemistry for imaging and detection.
• Proteomics Research: Used as a site-specific labeling reagent in activity-based protein profiling (ABPP) and enzyme studies.
• Antibody-Drug Conjugate (ADC) Development: Acts as a linker-payload component, connecting cytotoxic agents to monoclonal antibodies.
• Polymer & Materials Science: Serves as a cross-linking agent or photopolymerization initiator in the synthesis of functional polymers and hydrogels.
• Diagnostic Assay Development: Incorporation into fluorescent sensors and diagnostic kits for high-sensitivity detection.
• Chemical Biology Tools: Synthesis of activity-based probes (ABPs) to study enzyme function and mechanism.

Basic Information

Product Name	3-Maleimido-4-Methyl-6,7-Methylenedioxycoumarin
CAS No.	97744-90-6
Molecular Formula	C₁₅H₉NO₆
Molecular Weight	299.24 g/mol
Synonyms	4-Methyl-6,7-methylenedioxycoumarin-3-maleimide; 3-Maleimidomethyl-4-methyl-6,7-methylenedioxycoumarin; 3-(Maleimidomethyl)-4-methyl-6,7-methylenedioxycoumarin; 3-Maleimido-4-methyl-6,7-(methylenedioxy)coumarin; MDC-Maleimide; Fluorescent Maleimide Coumarin Derivative; Thiol-reactive Coumarin Probe
EINECS	Contact for details

Quality Control

Our 3-Maleimido-4-Methyl-6,7-Methylenedioxycoumarin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.